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Contract Opportunity

Description:

This is a notice of intent, not a request for a quotation. A solicitation document will not be issued, and quotations will not be requested.

The Department of Laboratory Medicine serves as the clinical laboratory of the NIH Clinical Center. It provides laboratory support for patient care and research protocols and performs research and training in disciplines of Clinical Pathology.

Line Items: Description Quantity

1002137 Freight charges1 1

937556 QIAsymphony DSP Circulating DNA Kit 6

990382 Sample Tubes CB (2ml) 4

997024 Filter-Tips, 1500 µl (1024) 8

Purpose:

A significant increase in circulating cell-free donor-derived DNA can be detected up to

five months before acute rejection can be diagnosed an invasive biopsy. To determine

donor-derived DNA, the genotyping procedure is essential. Laboratory of Applied

Precision Omics on the potential uses of cell free DNA technology requires the use of

QIAGEN’s high throughput automation process on the QiaSymphony SP, 34311 with the

DSP Circulating DNA kit to isolate nucleic acids

Scope of Work:

Next generation sequencing of cell-free DNA, genomic DNA, and mitochondrial DNA are among the nucleic acids of interest which are required for answering the primary and secondary endpoints of the Genome Transplant Dynamics study. Numerous intramural investigators have contacted the Laboratory of Transplantation Genomics regarding a mutual interest in investigating questions surrounding detection, diagnosis, and clinical utility of solid and liquid organ transplant rejection alike.

The laboratory of applied precision omics requires the purchase of Qiagen’s QIAsymphony DSP Circulation DNA Kit for processing patient samples by epMotion 5075 to automate the process of NGS library construction for 5 extramural-site research protocol which targets heart and lung transplant recipients. To determine cell-free DNA to risk stratify patients for severe COVID-19 and donor-derived DNA, the genotyping procedure and qualification of DNA is essential for high throughput automation of NGS library, and sensitive for cell free DNA.

Interested parties may identify their interest and capabilities in response to this posting. The determination by the Government not to compete the proposed requirement based upon responses to this notice is solely within the discretion of the Government.

Comments to this announcement, referencing this posting number, may be submitted to the Office of Purchasing and Contracts, prior to the closing date specified in this announcement, electronically to the attention of Damien Goines, Contract Specialist, damien.goines@nih.gov by MAY 13TH, 2024, 6:30AM EST.

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