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Contract Opportunity

Introduction

This is a Sources Sought Notice. This is NOT a solicitation for proposals, proposal abstracts, or quotations. The purpose of this notice is to obtain information regarding the availability and capability of all qualified sources to perform a potential requirement.

Background, Purpose, Objectives

The Vaccine Research Center (VRC) at the National Institutes of Health (NIH) was established to facilitate research in vaccine development. The VRC Virology Laboratory comprises the Virology, Humoral Immunology, and Structural Biology Sections and related Cores. The goal of the Virology Laboratory is to conduct research to understand better the cellular and molecular regulation of viral gene expression, viral entry into the host cell, optimization of immune responses to gene-based vaccination and correlates of immune protection, assessment of active and passive approaches for HIV-1 vaccine development, and to apply structural biology techniques toward rational vaccine design for emerging and re-emerging infectious diseases.

The Vaccine Research Center is developing vaccines for HIV-1 and other viruses. Currently, SBS/SBIS is working on developing vaccines for SARS-CoV-2. Production of wild-type and mutant viral proteins and anti-viral antibodies is critical in vaccine development. Making specific immunogens as probes is critical to isolate antibodies and develop therapeutic agents in the Covid19 treatment.

The Virology Laboratory is interested in procuring Streptavidin (SA) Biosensors from Sartorius Corporation for measuring protein-protein interactions, including Sera readout in ongoing immunization experiments on an Octet HTX system. This request is for a consumable to be used on this system.

Project Requirements

Successful offerors must have the knowledge, skill, ability, and resources to reliably provide a brand name or equal set of Streptavidin biosensors as follows. Note, the biosensors must be compatible with OCTECT HTX system. Minimum requirements of the type of biosensors to be used on this system can be found at Octet_HTX_datasheet.pdf

Octet® Streptavidin (SA) Biosensors / Case: Anti-human IgG Fc Capture Biosensors - Twenty trays of 96 biosensors coated with streptavidin for quantitation, screening, or kinetic applications. Material No. 18-5021, QTY of 1 case

• Anti-human IgG Fc Capture Biosensors - Twenty trays of 96 biosensors for the immobilization of human IgG or other proteins containing the human Fc region for kinetic analysis. Material No. 18-5064, QTY of 1 case


• Ni-NTA (NTA) Biosensors - Twenty trays of 96/case biosensors coated with nickel-charged tris-NTA for both quantitation and kinetic applications of HIS-tagged molecules. Material No. 18-5103, QTY of 1 case


• Anti-Penta-HIS (HIS1K) Biosensors - Twenty trays of 96/case biosensors coated with the Qiagen Penta-HIS antibody for quantitation and kinetics applications. Material No. 18-5122


• Shipping and Handling QTY of 1

The Government anticipates awarding a firm fixed price purchase order, after solicitation for this requirement.

Date of Delivery: 30 days from ARO

Place of Delivery

Bethesda, MD 20892

Capability Statement/Information Sought

All capable vendors should respond with a brief capability statement by April 29, 2024 at 10:00 AM EST. The capability statement must include the ability to provide the required brand name or equal products, as per specifications, and that are compatible with the OCTET HTX System.

Executive Order 14005-Ensuring the Future Is Made in All of America by All of America's Workers. “Buy America” or “Buy American,” that require, or provide a preference for, the purchase or acquisition of goods, products, or materials produced in the United States, including iron, steel, and manufactured goods offered in the United States." Capability statement must include place of manufacturer.

If your organization has the potential capacity to support this requirement, please provide the following information: 1) organization name, address, point of contact, email address, website address, telephone number, UEI number and size and type of ownership for the organization; and 2) respondents shall indicate if they are the manufacturer or the distributor of Streptavidin biosensors and shall include basic information on product specifications. If an equal product is recommended (not specific to the brand proposed) then sufficient details shall be provided by the respondent describing how the equal product being recommended, meets the minimum specifications of the requirement.

Capability statements should also include documentation indicating that offerors business size as determined by the Small Business Administration’s Table of Size Standards located at: (https://www.sba.gov/content/small-business-size-standards) for NAICS 325414. This SBA size standard is currently 1250 employees but is subject to change. Prospective offerors may also note whether they meet any other socio-economic business categories such as 8(a), Hub-Zone, or Service-Disabled Veteran when submitting their capability statement.

Submission Instructions

Interested businesses who consider themselves qualified to provide the above-listed items are invited to submit a response to this Sources Sought Notice by April 29, 2024 at 10:00 AM EST. All responses under this Sources Sought Notice must be submitted via the NIAID electronic Simplified Acquisition Submission System (eSASS) website at https://esass.nih.gov. All vendors must register in the eSASS system to submit their documentation. Instructions on how to register

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